The former Liverpool winger emerged as a major doubt for the tournament after injuring his ankle on Tuesday against Werder Bremen.
Mane hobbled off and looked in obvious pain when he left the Allianz Arena pitch.
In a statement, Bayern Munich said: “Sadio Mane has picked up an injury and he won’t be available for game against Schalke.
“Further tests will follow in the next few days — Bayern is in contact with the medical team of Senegalese Football Association.”
Despite the concerns, believe that Mane will be named in the squad on Friday.
According to sources, Mane “remains calm” about the situation.
The 30-year-old has been in excellent form for Bayern following his summer move from Liverpool, netting 11 goals.
But Mane has been even more clutch for his country in 2022.
Firstly, he scored the winning penalty in February as Senegal beat Egypt to win the Africa Cup of Nations for the first time ever.
He repeated the feat two months later when he once again scored the decisive kick against old Liverpool pal Mo Salah in a World Cup play-off to help Senegal secure their place in Qatar.
Mane is his country’s all-time leading scorer and would be one of the most experienced players in Aliou Cisse’s squad.
